Ototoxicity from cisplatin

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August undefined, 2024

WebApr 5, 2024 · Ototoxicity is defined as damage to structures and function of the auditory-vestibular system caused by exogenous agents, such as chemotherapy. 1 Cisplatin is a … WebMay 19, 2016 · He is actively involved in several human clinical trials looking at the prevention of cisplatin ototoxicity that may drastically decrease the …

Cisplatin-Induced Ototoxicity: A Concise Review of the Burden ...

WebApr 26, 2024 · Cisplatin is a highly effective antineoplastic agent used to treat solid tumors. Unfortunately, the administration of this drug leads to significant side effects, including … WebFrom these, doxorubicin, high-dose methotrexate, cisplatin, and, to a lesser extent, ifosfamide have emerged as the most active. Others such as ... et al. Prevention of … safe disposal of industrial waste

Ototoxicity in Children With High-Risk Neuroblastoma: Prevalence, …

WebJun 18, 2024 · Ototoxicity monitoring is uncommon in South Africa, despite the increased use of ototoxic medication to manage the burden of disease in the country. The … WebAug 31, 2016 · Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential places cancer patients, exposed to this drug, at risk of hearing loss, … WebDec 29, 2024 · The list includes aminoglycosides and other antibiotics, platinum-based antineoplastic agents, salicylates, quinine, and loop diuretics. An image depicting inner ear anatomy can be seen below. Inner ear anatomy. Ototoxicity is typically associated with bilateral high-frequency sensorineural hearing loss and tinnitus. ishitasingh301

Association of Sodium Thiosulfate With Risk of Ototoxic Effects

The Burden and Current Management of Cisplatin-Induced …

WebApr 7, 2024 · Determining the mechanism behind this adverse effect could possibly aid in developing strategies to mitigate it. Potential mechanisms for cisplatin-induced ototoxicity include direct cytotoxicity from the platinum-containing agent, direct damage to DNA, or induction of apoptosis through mechanisms involving cell cycle arrest and/or generation … WebSep 20, 2024 · The incidence of hearing loss was lower in the sodium thiosulfate and cisplatin arm (39%) compared with the cisplatin alone arm (68%); unadjusted relative risk … ishitegawaWebJul 15, 2015 · Cisplatin is a highly effective chemotherapeutic agent that is widely used to treat solid organ malignancies. However, serious side effects have been associated with … safe disposal of chemicals

"WebSep 2, 2024 · Ototoxicity From Cisplatin: Who Is at Risk and Who May Benefit From Treatment? The highest buildup of cisplatin was in the stria vascularis, which helps … " - Ototoxicity from cisplatin

Ototoxicity from cisplatin

Hear Me Out: Mitigating Cisplatin-Induced Ototoxicity

WebOct 27, 2024 · A mouse model with cisplatin-induced ototoxicity was used in addition to human samples from the ITMAT Biobank at the University of Pennsylvania. Mouse … WebSep 1, 2024 · Improving Ototoxicity Monitoring with Cisplatin Therapy at VA Northeast Ohio Healthcare System (VANOHS), An Interdisciplinary Team Approach. Publish date: …

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WebJun 21, 2024 · The relative risk of any hearing loss with cisplatin–sodium thiosulfate treatment was 0.52 (95% CI, 0.33 to 0.81), which translates to a 48% lower risk with … WebApr 4, 2024 · Background Concurrent chemoradiotherapy using weekly cisplatin remains standard of care for locally advanced cervical cancer in Sub-Saharan Africa. While …

WebMar 29, 2024 · Platinum-based agents are a standard chemotherapy treatment for malignancies in both pediatric and adult populations. 1 However, mitigating and managing chemotherapy-associated adverse events remains a concern. 2 Ototoxicity is a well-documented side effect of these platinum-based agents, especially cisplatin. This hearing … WebCisplatin-induced ototoxicity is caused by reactive oxygen species. It has been recognized that estradiol (E2) regulates redox balance. However, little is known about the protective …

WebMar 5, 2024 · Ototoxicity is one of the major side-effects of platinum-based chemotherapy, in particular cisplatin (cis-diammine dichloroplatinum II). To our knowledge, no … WebSep 24, 2024 · The effects of cisplatin ototoxicity are irreversible and permanent; certain is the fact that it will decrease in the quality of life of a cancer survivor. Varying degrees of damage have been reported: some patients experience persistent ringing in the ear or dizziness, while others found it difficult to communicate because they cannot hear properly.

Weboptimal ototoxicity grading. Furthermore, prevalence and predictors of hearing loss in a large uniformly treated high-risk neuroblastoma population are unknown. We address …

WebOf these reactions, cisplatin-induced nephrotoxicity (CIN), cisplatin-induced peripheral neuropathy (CIPN), and cisplatin-induced ototoxicity (CIO) are the three most common of several CITs recognised thus far. While the anti-cancer activity of cisplatin is well understood, the mechanisms driving its toxicities have only begun to be defined. ishitarathi08.wordpress.comWebA clinical and pathologic study of cis-platinum ototoxicity was performed. Twenty-four patients treated with cis-platinum for head and neck cancer were studied prospectively. Post cis-platinum hearing losses were subclinical, detected in 25% of patients, isolated to 4 and 8 kHz, and did not exceed 25 dB at any frequency. ishitani health center - fort lee nj 07024 safe diets to lose weight fastWebJan 26, 2024 · Cisplatin, a platinum-based chemotherapy drug, is commonly used for the treatment of many cancers, including bladder, ovarian, and testicular cancers. But … safe dishwasher detergent for babyWebMar 6, 2024 · With 74% of testicular cancer survivors reporting hearing loss in a recent study, one expert advised patients to advocate for themselves and their hearing before, during and after cancer treatment with cisplatin-based chemotherapy. Three out of four testicular cancer survivors reported experiencing ototoxicity — damage to the inner ear caused ... ishitherWebPlatinum-based chemotherapy is commonly used to treat germ cell tumors (GCT) but can cause detrimental health effects, including ototoxicity and tinnitus. Years after the … safe disposable containers to take to friendWebpermanent. Symptoms of ototoxicity include tinnitus, dizziness, and difficulty understanding speech in noise. Approximately 4 million patients annually in the United States are at risk for hearing loss from aminoglycoside antibiotics (e.g. gentamicin) and plati-num-based chemotherapy agents (e.g., cisplatin). Loop ishite book cafe